A study in rodents suggests that Cordyceps sinensis may ameliorate the suppressive effects of chemotherapy on bone marrow function.
Chemotherapy can cause a condition known as leukopenia, an abnormal decrease of white blood cells. This effect is often due to chemotherapy’s effects on the bone marrow, where the white blood cells known as leukocytes are formed from undifferentiated stem cells that give rise to all blood cells.
To test Cordyceps sinensis’ effects on white blood cells, researchers gave mice a chemotherapy drug one day before the animals were given 50 mg/kg per day Cordyceps sinensis, through oral administration, for 3 weeks. White blood cell counts in peripheral blood of mice receiving the chemotherapy agent without the Cordyceps sinensis were at 50 percent of normal levels on day 28. However, the white blood cell counts in the peripheral blood of mice that had received Cordyceps sinensis recovered completely to normal levels.
In vitro assays showed that Cordyceps sinensis enhanced the colony-forming ability of both macrophages and cells from bone marrow preparations. Cordyceps sinensis was able to protect progenitor (stem) cells by influencing the activity of osteoblasts (bone-building cells). It had a number of positive effects on bone marrow cells, osteoblasts, and bone tissue.
The researchers concluded that CS enhances recovery of mice from leukopenia caused by chemotherapy treatment.
Reference:
Liu WC, Chuang WL, Tsai ML, Hong JH, McBride WH, Chiang CS. Cordyceps sinensis Health Supplement Enhances Recovery from Taxol-Induced Leukopenia. Exp Biol Med (Maywood). 2008 Apr;233(4):447-55
Chemotherapy can cause a condition known as leukopenia, an abnormal decrease of white blood cells. This effect is often due to chemotherapy’s effects on the bone marrow, where the white blood cells known as leukocytes are formed from undifferentiated stem cells that give rise to all blood cells.
To test Cordyceps sinensis’ effects on white blood cells, researchers gave mice a chemotherapy drug one day before the animals were given 50 mg/kg per day Cordyceps sinensis, through oral administration, for 3 weeks. White blood cell counts in peripheral blood of mice receiving the chemotherapy agent without the Cordyceps sinensis were at 50 percent of normal levels on day 28. However, the white blood cell counts in the peripheral blood of mice that had received Cordyceps sinensis recovered completely to normal levels.
In vitro assays showed that Cordyceps sinensis enhanced the colony-forming ability of both macrophages and cells from bone marrow preparations. Cordyceps sinensis was able to protect progenitor (stem) cells by influencing the activity of osteoblasts (bone-building cells). It had a number of positive effects on bone marrow cells, osteoblasts, and bone tissue.
The researchers concluded that CS enhances recovery of mice from leukopenia caused by chemotherapy treatment.
Reference:
Liu WC, Chuang WL, Tsai ML, Hong JH, McBride WH, Chiang CS. Cordyceps sinensis Health Supplement Enhances Recovery from Taxol-Induced Leukopenia. Exp Biol Med (Maywood). 2008 Apr;233(4):447-55
1 comment:
There are various advantages that the Cordyceps sinensis provides us and it is because of so many important minerals that it contains. It contains many different types of amino acids as well as sterols that are very important nutrients.
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